How CCMS can accelerate your drug discovery and development efforts

The costs of clinical development are high and constantly increasing, estimates in the hundreds of million of dollars for the cumulative success and failures required to bring a single new drug to market.

caprotec´s Capture Compound™ Technology (CCMS) is poised to deliver powerful insights into small molecule-target interactions and binding affinities across the proteome in biological samples of various origins. A drugs´ therapeutic performance is based on the interaction with proteins such as enzymes and receptors. Specific structural features of the drug molecule are guiding it to bind to the therapeutically important target protein. Unfortunately, some structural features are guiding it to proteins (OFF-target proteins) causing in some cases life threatening side effects.

 

CCMS helps to find answers to the following questions:

• Which proteins interact with the drug?

• Which interacting proteins lead to the therapeutic effect?

• Which interacting proteins lead to side effects?

• How need drugs to be improved based on this knowledge?

• Shall the drug be used for the next phase in clinical trials?

 

In drug development CCMS will help to determine the mechanism of drug action and the drug-protein interaction profile to sort out the best and most promising drug candidate before entering the expensive and time-consuming clinical trial process.

Discovery - In early stage of drug development CCMS can identify On- and Off-target proteins.

Identification - In lead optimization CCMS can identify leads with no or uncritical OFF-target binding for further preclinical and clinical development.

Profiling - In toxicology studies CCMS can identify proteins responsible for toxic effects and determine the relevance of toxic effects.

 

Taken together CCMS can address today´s lack of technologies to analyze and avoid negative side effects very early in the drug development process ("early fail") by delivering the right information to optimize the chemical structure of a development candidate.

caprotec´s CCMS is dedicated to accelerate your drug development with individually customized kits, development collaborations or contract research.

caprotec™ bioanalytics offers the synthesis of customized Capture Compounds with a selectivity function based on small molecules of your choice. The design and synthesis of customized Capture Compounds is an interactive process. We will work closely with your team to define the experimental design that will most effectively support your application.

For more information on customized Capture Compounds for all stages of drug discovery and development please contact us.

• CCMS: A New Era in Toxicoproteomics

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• Capture Compound™ Mass Spectrometry: A Technology for the Investigation of Small Molecule Protein Interactions

  One of the major hurdles in the post-genomic era is to understand the function of genes and the interplay of many different cellular proteins.
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