Advantages of CCMS compared to other methods
Quality control:
Capture Compounds™ are small molecules, thus their integrity can be unambiguously assessed by analytical methods. A coupling of ligands or proteins to a solid support is not necessary.
Ligand accessibility:
The Capture Compound™ protein interaction is taking place in a homogeneous solution, no solid phase interactions are required during the critical affinity interaction to capture protein targets, no bias with regards to protein size is created.
Solubility:
Capture Compounds™ can be modified to react in hydrophilic and lipophilic environments, allowing to investigate a wide range of target proteins.
Dynamic range:
Weak and strong interacting proteins can be identified by varying the ratio of Capture Compound™ to protein. Stringent wash conditions can be employed even with low affinity binders due to the covalent photo cross-linking.
- Advantages of Capture Compounds Mass Spectrometry in comparison to bifunctional molecules, affinity chromatography and immune precipitation
Download Advantages of Capture Compounds Mass Spectrometry in comparison of bifunctional molecules, affinity chromatography and immune precipitation (2.8 MB, high resolution).
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